The General Assembly (GA) is the topmost organ and comprises representatives of malaria R&D institutions in Africa and allied institutions outside Africa. The GA Meets every 2 years and is responsible for electing the Board of Trustees and the Scientific Coordinating Committee.

The Board of Trustees (BoT)
This is the ultimate authority in matters of policy and investment. The BoT oversees the general governance, regulation and control of AMANET.

Currently, the members of the Board are:

Prof. Robert Guiguemde, Burkina Faso,
Prof. Yadon M Kohi, Tanzania
Prof. Wenceslaus L Kilama, Tanzania, Secretary
Prof. Rose Leke, Cameroon
Prof. Marcel Tanner, Switzerland
Dr. Louis Miller, USA
Dr. Regina Rabinovich, USA
Dr. Dan Kaseje, Kenya
Dr. Hassan Mshida, Tanzania
Dr. Søren Jepsen, Denmark

The Scientific Coordinating Committee (SCC)
Is constituted of senior research scientists elected by the General Assembly. The SCC is responsible for receiving and reviewing reports from the Secretariat and from the Expert Committees. It also advises the BoT on scientific matters. Another function of the SCC is reviewing research proposals and letters of expression of interest and M&E of ongoing and completed research projects.

The Trial Sites Developing Committee (TSDC) is drawn from the SCC and is appointed by the BoT. TSDC advises AMANET on all matters concerning malaria intervention trial sites.

The Secretariat
The Executive organ of the Trust,
Serves the Board of Trustees and all the committees.
Currently it comprises the following:
1. Managing Trustee: Prof W. L. Kilama
2. Network Director: Prof J. A. Oloo
3. Clinical Trials Coordinator: Dr R. Chilengi
4. Projects and Sites Manager: Dr R. A. Noor
5. Ethics Coordinator: Dr A. Nyika
6. Finance & Administration Manager: Mr B. B. Amri
7. Communications Officer: Dr C. L. Wanga
8. Information Technology Officer: Mr S. W. Ramadhani
9. Accounts and Procurement Officer: Mr B. G. Majila
10. Executive Assistant: Ms. Leila Mfinanga
11. Personal Secretary: Ms S. N. Mandawa